{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/heterogeneity-in-temporally-fluctuating","title":"Phenotypic heterogeneity in temporally fluctuating environments","arxiv_id":"2411.03166","date":"2024-11-05","proceeding":null,"authors":["Alexander P Browning","Sara Hamis"],"abstract":"Many biological systems regulate phenotypic heterogeneity as a fitness-maximising strategy in uncertain and dynamic environments. Analysis of such strategies is typically confined both to a discrete set of environmental conditions, and to a discrete (often binary) set of phenotypes specialised to each condition. In this work, we extend theory on both fronts to encapsulate both a discrete and continuous spectrum of phenotypes arising in response to two broad classes of environmental efluctuations that drive changes in the phenotype-dependent growth rates; specifically, stochastic environments that are temporally uncorrelated (specifically, white-noise processes) and correlated (specifically, Poisson and Ornstein-Uhlenbeck processes). For tractability, we restrict analysis to an exponential growth model, and consider biologically relevant simplifications that pertain to the relative timescale of phenotype switching. These assumptions yield a series of analytical and semi-analytical expressions that reveal environments in which both discrete and continuous phenotypic heterogeneity is evolutionary advantageous.","url_abs":"https://arxiv.org/abs/2411.03166v2","url_pdf":"https://arxiv.org/pdf/2411.03166v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"heterogeneity-in-temporally-fluctuating","repo_url":"https://github.com/ap-browning/heterogeneity","is_official":1,"mentioned_in_paper":0,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[],"methods":[{"method_slug":"set","method_name":"SET"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}