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Existing methods primarily focus on pair-wise interaction of body joints, which is insufficient for scenarios involving overlapping joints and rapidly changing poses. To overcome these issues, we introduce a novel approach, the High-order Directed Transformer (HDFormer), which leverages high-order bone and joint relationships for improved pose estimation. Specifically, HDFormer incorporates both self-attention and high-order attention to formulate a multi-order attention module. This module facilitates first-order \"joint$\\leftrightarrow$joint\", second-order \"bone$\\leftrightarrow$joint\", and high-order \"hyperbone$\\leftrightarrow$joint\" interactions, effectively addressing issues in complex and occlusion-heavy situations. In addition, modern CNN techniques are integrated into the transformer-based architecture, balancing the trade-off between performance and efficiency. HDFormer significantly outperforms state-of-the-art (SOTA) models on Human3.6M and MPI-INF-3DHP datasets, requiring only 1/10 of the parameters and significantly lower computational costs. Moreover, HDFormer demonstrates broad real-world applicability, enabling real-time, accurate 3D pose estimation. 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