{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/generative-deep-learning-enabled-ultra-large","title":"Physics-informed generative real-time lens-free imaging","arxiv_id":"2403.07786","date":"2024-03-12","proceeding":null,"authors":["Ronald B. Liu","Zhe Liu","Max G. A. Wolf","Krishna P. Purohit","Gregor Fritz","Yi Feng","Carsten G. Hansen","Pierre O. Bagnaninchi","Xavier Casadevall i Solvas","Yunjie Yang"],"abstract":"Advancements in high-throughput biomedical applications require real-time, large field-of-view (FOV) imaging. While current 2D lens-free imaging (LFI) systems improve FOV, they are often hindered by time-consuming multi-position measurements, extensive data pre-processing, and strict optical parameterization, limiting their application to static, thin samples. To overcome these limitations, we introduce GenLFI, combining a generative unsupervised physics-informed neural network (PINN) with a large FOV LFI setup for straightforward holographic image reconstruction, without multi-measurement. GenLFI enables real-time 2D imaging for 3D samples, such as droplet-based microfluidics and 3D cell models, in dynamic complex optical fields. Unlike previous methods, our approach decouples the reconstruction algorithm from optical setup parameters, enabling a large FOV limited only by hardware. We demonstrate a real-time FOV exceeding 550 mm$^2$, over 20 times larger than current real-time LFI systems. This framework unlocks the potential of LFI systems, providing a robust tool for advancing automated high-throughput biomedical applications.","url_abs":"https://arxiv.org/abs/2403.07786v4","url_pdf":"https://arxiv.org/pdf/2403.07786v4.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"generative-deep-learning-enabled-ultra-large","repo_url":"https://github.com/rl-arch/lensgan","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"drug-discovery","task_name":"Drug Discovery"},{"task_slug":"image-reconstruction","task_name":"Image Reconstruction"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}