{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/generalizable-synthetic-mri-with-physics","title":"Generalizable synthetic MRI with physics-informed convolutional networks","arxiv_id":"2305.12570","date":"2023-05-21","proceeding":null,"authors":["Luuk Jacobs","Stefano Mandija","Hongyan Liu","Cornelis A. T. van den Berg","Alessandro Sbrizzi","Matteo Maspero"],"abstract":"In this study, we develop a physics-informed deep learning-based method to synthesize multiple brain magnetic resonance imaging (MRI) contrasts from a single five-minute acquisition and investigate its ability to generalize to arbitrary contrasts to accelerate neuroimaging protocols. A dataset of fifty-five subjects acquired with a standard MRI protocol and a five-minute transient-state sequence was used to develop a physics-informed deep learning-based method. The model, based on a generative adversarial network, maps data acquired from the five-minute scan to \"effective\" quantitative parameter maps, here named q*-maps, by using its generated PD, T1, and T2 values in a signal model to synthesize four standard contrasts (proton density-weighted, T1-weighted, T2-weighted, and T2-weighted fluid-attenuated inversion recovery), from which losses are computed. The q*-maps are compared to literature values and the synthetic contrasts are compared to an end-to-end deep learning-based method proposed by literature. The generalizability of the proposed method is investigated for five volunteers by synthesizing three non-standard contrasts unseen during training and comparing these to respective ground truth acquisitions via contrast-to-noise ratio and quantitative assessment. The physics-informed method was able to match the high-quality synthMRI of the end-to-end method for the four standard contrasts, with mean \\pm standard deviation structural similarity metrics above 0.75 \\pm 0.08 and peak signal-to-noise ratios above 22.4 \\pm 1.9 and 22.6 \\pm 2.1. Additionally, the physics-informed method provided retrospective contrast adjustment, with visually similar signal contrast and comparable contrast-to-noise ratios to the ground truth acquisitions for three sequences unused for model training, demonstrating its generalizability and potential application to accelerate neuroimaging protocols.","url_abs":"https://arxiv.org/abs/2305.12570v1","url_pdf":"https://arxiv.org/pdf/2305.12570v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"generalizable-synthetic-mri-with-physics","repo_url":"https://gitlab.com/computational-imaging-lab/qstarmri","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":null,"task_name":"Generative Adversarial Network"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}