{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/gap-junction-plasticity-can-lead-to-spindle","title":"Gap junction plasticity can lead to spindle oscillations","arxiv_id":"1710.03999","date":"2017-10-11","proceeding":null,"authors":["Guillaume Pernelle","Wilten Nicola","Claudia Clopath"],"abstract":"Patterns of waxing and waning oscillations, called spindles, are observed in multiple brain regions during sleep. Spindle are thought to be involved in memory consolidation. The origin of spindle oscillations is ongoing work but experimental results point towards the thalamic reticular nucleus (TRN) as a likely candidate. The TRN is rich in electrical synapses, also called gap junctions, which promote synchrony in neural activity. Moreover, gap junctions undergo activity-dependent long-term plasticity. We hypothesized that gap junction plasticity can modulate spindle oscillations. We developed a computational model of gap junction plasticity in recurrent networks of TRN and thalamocortical neurons (TC). We showed that gap junction coupling can modulate the TRN-TC network synchrony and that gap junction plasticity is a plausible mechanism for the generation of sleep-spindles. Finally, our results are robust to the simulation of pharmacological manipulation of spindles, such as the administration of propofol, an anesthetics known to generate spindles in humans.","url_abs":"http://arxiv.org/abs/1710.03999v1","url_pdf":"http://arxiv.org/pdf/1710.03999v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"links_only","authors_date_abstract":"arXiv metadata, CC0 1.0 (https://info.arxiv.org/help/license), from the Kaggle arXiv metadata snapshot of 2026-09-12"},"code_links":[{"paper_slug":"gap-junction-plasticity-can-lead-to-spindle","repo_url":"https://github.com/gpernelle/spindles_with_gap_junctions","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":1,"framework":"tf","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}