{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/distinguishing-cell-phenotype-using-cell","title":"Distinguishing Cell Phenotype Using Cell Epigenotype","arxiv_id":"2003.09432","date":"2020-03-20","proceeding":null,"authors":["Thomas P. Wytock","Adilson E. Motter"],"abstract":"The relationship between microscopic observations and macroscopic behavior is a fundamental open question in biophysical systems. Here, we develop a unified approach that---in contrast with existing methods---predicts cell type from macromolecular data even when accounting for the scale of human tissue diversity and limitations in the available data. We achieve these benefits by applying a k-nearest-neighbors algorithm after projecting our data onto the eigenvectors of the correlation matrix inferred from many observations of gene expression or chromatin conformation. Our approach identifies variations in epigenotype that impact cell type, thereby supporting the cell type attractor hypothesis and representing the first step toward model-independent control strategies in biological systems.","url_abs":"https://arxiv.org/abs/2003.09432v1","url_pdf":"https://arxiv.org/pdf/2003.09432v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"distinguishing-cell-phenotype-using-cell","repo_url":"https://github.com/twytock/Distinguishing_Cell_Types","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[{"task_slug":"diversity","task_name":"Diversity"},{"task_slug":"open-question","task_name":"Open-Ended Question Answering"},{"task_slug":"type","task_name":"Vocal Bursts Type Prediction"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}