{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/different-roles-for-inhibition-in-the-rhythm","title":"Different roles for inhibition in the rhythm-generating respiratory network","arxiv_id":"1610.04258","date":"2017-06-12","proceeding":null,"authors":[],"abstract":"Unraveling the interplay of excitation and inhibition within\nrhythm-generating networks remains a fundamental issue in neuroscience. We use\na biophysical model to investigate the different roles of local and long-range\ninhibition in the respiratory network, a key component of which is the\npre-B\\\"otzinger complex inspiratory microcircuit. Increasing inhibition within\nthe microcircuit results in a limited number of out-of-phase neurons before\nrhythmicity and synchrony degenerate. Thus, unstructured local inhibition is\ndestabilizing and cannot support the generation of more than one rhythm. A\ntwo-phase rhythm requires restructuring the network into two microcircuits\ncoupled by long-range inhibition in the manner of a half-center. In this\ncontext, inhibition leads to greater stability of the two out-of-phase rhythms.\nWe support our computational results with in vitro recordings from mouse\npre-B\\\"otzinger complex. Partial excitation block leads to increased rhythmic\nvariability, but this recovers following blockade of inhibition. Our results\nsupport the idea that local inhibition in the pre-B\\\"otzinger complex is\npresent to allow for descending control of synchrony or robustness to adverse\nconditions like hypoxia. We conclude that the balance of inhibition and\nexcitation determines the stability of rhythmogenesis, but with opposite roles\nwithin and between areas. These different inhibitory roles may apply to a\nvariety of rhythmic behaviors that emerge in widespread pattern generating\ncircuits of the nervous system.","url_abs":"http://arxiv.org/abs/1610.04258v2","url_pdf":"http://arxiv.org/pdf/1610.04258v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"different-roles-for-inhibition-in-the-rhythm","repo_url":"https://github.com/kharris/prebotc-graph-model","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[{"task_slug":"rhythm","task_name":"Rhythm"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}