{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/development-of-rlk-unet-a-clinically","title":"Development of RLK-Unet: a clinically favorable deep learning algorithm for brain metastasis detection and treatment response assessment","arxiv_id":null,"date":"2024-01-14","proceeding":"Frontiers in Oncology 2024 1","authors":["Seungyeon Son","Bio Joo","Mina Park","Sang Hyun Suh","Hee Sang Oh","Jun Won Kim","Seoyoung Lee","Sung Jun Ahn*†","Jong-Min Lee*†"],"abstract":"Purpose/objective(s): Previous deep learning (DL) algorithms for brain metastasis (BM) detection and segmentation have not been commonly used in clinics because they produce false-positive findings, require multiple sequences, and do not reflect physiological properties such as necrosis. The aim of this study was to develop a more clinically favorable DL algorithm (RLK-Unet) using a single sequence reflecting necrosis and apply it to automated treatment response assessment.\r\n\r\nMethods and materials: A total of 128 patients with 1339 BMs, who underwent BM magnetic resonance imaging using the contrast-enhanced 3D T1 weighted (T1WI) turbo spin-echo black blood sequence, were included in the development of the DL algorithm. Fifty-eight patients with 629 BMs were assessed for treatment response. The detection sensitivity, precision, Dice similarity coefficient (DSC), and agreement of treatment response assessments between neuroradiologists and RLK-Unet were assessed.\r\n\r\nResults: RLK-Unet demonstrated a sensitivity of 86.9% and a precision of 79.6% for BMs and had a DSC of 0.663. Segmentation performance was better in the subgroup with larger BMs (DSC, 0.843). The agreement in the response assessment for BMs between the radiologists and RLK-Unet was excellent (intraclass correlation, 0.84).\r\n\r\nConclusion: RLK-Unet yielded accurate detection and segmentation of BM and could assist clinicians in treatment response assessment.","url_abs":"https://doi.org/10.3389/fonc.2023.1273013","url_pdf":"https://github.com/nibabel/RLK_Unet/files/14135545/fonc-13-1273013.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"development-of-rlk-unet-a-clinically","repo_url":"https://github.com/nibabel/RLK-Unet","is_official":1,"mentioned_in_paper":0,"mentioned_in_github":0,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"brain-tumor-segmentation","task_name":"Brain Tumor Segmentation"},{"task_slug":"image-segmentation","task_name":"Image Segmentation"},{"task_slug":"lesion-segmentation","task_name":"Lesion Segmentation"},{"task_slug":"medical-image-segmentation","task_name":"Medical Image Segmentation"},{"task_slug":"segmentation","task_name":"Segmentation"},{"task_slug":"sensitivity","task_name":"Sensitivity"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}