{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/deuteros-2-0-peptide-level-significance","title":"Deuteros 2.0: Peptide-level significance testing of data from hydrogen deuterium exchange mass spectrometry","arxiv_id":"2005.08380","date":"2020-05-17","proceeding":null,"authors":[],"abstract":"Summary: Hydrogen deuterium exchange mass spectrometry (HDX-MS) is becoming\nincreasing routine for monitoring changes in the structural dynamics of\nproteins. Differential HDX-MS allows comparison of individual protein states,\nsuch as in the absence or presence of a ligand. This can be used to attribute\nchanges in conformation to binding events, allowing the mapping of entire\ncon-formational networks. As such, the number of necessary cross-state\ncomparisons quickly increas-es as additional states are introduced to the\nsystem of study. There are currently very few software packages available that\noffer quick and informative comparison of HDX-MS datasets and even few-er which\noffer statistical analysis and advanced visualization. Following the feedback\nfrom our origi-nal software Deuteros, we present Deuteros 2.0 which has been\nredesigned from the ground up to fulfil a greater role in the HDX-MS analysis\npipeline. Deuteros 2.0 features a repertoire of facilities for back exchange\ncorrection, data summarization, peptide-level statistical analysis and advanced\ndata plotting features. Availability: Deuteros 2.0 can be downloaded from\nhttps://github.com/andymlau/Deuteros_2.0 under the Apache 2.0 license.\nInstallation of Deuteros 2.0 requires the MATLAB Runtime Library available free\nof charge from MathWorks\n(https://www.mathworks.com/products/compiler/matlab-runtime.html) and is\navailable for both Windows and Mac operating systems.","url_abs":"http://arxiv.org/abs/2005.08380v1","url_pdf":"http://arxiv.org/pdf/2005.08380v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"deuteros-2-0-peptide-level-significance","repo_url":"https://github.com/andymlau/Deuteros_2.0","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[{"task_slug":"attribute","task_name":"Attribute"},{"task_slug":"data-summarization","task_name":"Data Summarization"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}