{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/detection-of-circular-permutations-by-protein","title":"Detection of circular permutations by Protein Language Models","arxiv_id":"2404.15087","date":"2024-04-23","proceeding":null,"authors":["Yue Hu","Bin Huang","Chunzi Zang"],"abstract":"Protein circular permutations are crucial for understanding protein evolution and functionality. Traditional detection methods, sequence-based or structure-based, struggle with accuracy and computational efficiency, the latter also limited by treating proteins as rigid bodies. The plmCP method, utilizing a protein language model, not only speeds up the detection process but also enhances the accuracy of identifying circular permutations, contributing significantly to protein research and engineering by acknowledging structural flexibility.","url_abs":"https://arxiv.org/abs/2404.15087v2","url_pdf":"https://arxiv.org/pdf/2404.15087v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"detection-of-circular-permutations-by-protein","repo_url":"https://github.com/yuehulab/plmcp","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"computational-efficiency","task_name":"Computational Efficiency"},{"task_slug":"language-modeling","task_name":"Language Modeling"},{"task_slug":"language-modelling","task_name":"Language Modelling"},{"task_slug":"protein-language-model","task_name":"Protein Language Model"}],"methods":[{"method_slug":"speed","method_name":"SPEED"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}