{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/deep-reinforcement-learning-for-control-of","title":"Deep Reinforcement Learning for Control of Probabilistic Boolean Networks","arxiv_id":"1909.03331","date":"2019-09-07","proceeding":null,"authors":["Georgios Papagiannis","Sotiris Moschoyiannis"],"abstract":"Probabilistic Boolean Networks (PBNs) were introduced as a computational model for the study of complex dynamical systems, such as Gene Regulatory Networks (GRNs). Controllability in this context is the process of making strategic interventions to the state of a network in order to drive it towards some other state that exhibits favourable biological properties. In this paper we study the ability of a Double Deep Q-Network with Prioritized Experience Replay in learning control strategies within a finite number of time steps that drive a PBN towards a target state, typically an attractor. The control method is model-free and does not require knowledge of the network's underlying dynamics, making it suitable for applications where inference of such dynamics is intractable. We present extensive experiment results on two synthetic PBNs and the PBN model constructed directly from gene-expression data of a study on metastatic-melanoma.","url_abs":"https://arxiv.org/abs/1909.03331v5","url_pdf":"https://arxiv.org/pdf/1909.03331v5.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"deep-reinforcement-learning-for-control-of","repo_url":"https://github.com/jakub-zarzycki2022/gym-pbn-stac","is_official":0,"mentioned_in_paper":0,"mentioned_in_github":1,"framework":"none","reach":null},{"paper_slug":"deep-reinforcement-learning-for-control-of","repo_url":"https://github.com/uos-plccn/gym-pbn","is_official":0,"mentioned_in_paper":0,"mentioned_in_github":1,"framework":"none","reach":null}],"tasks":[{"task_slug":"deep-reinforcement-learning","task_name":"Deep Reinforcement Learning"},{"task_slug":"q-learning","task_name":"Q-Learning"},{"task_slug":"reinforcement-learning","task_name":"Reinforcement Learning"},{"task_slug":"reinforcement-learning-1","task_name":"Reinforcement Learning (RL)"},{"task_slug":"reinforcement-learning-2","task_name":"reinforcement-learning"}],"methods":[{"method_slug":"experience-replay","method_name":"Experience Replay"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}