{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/comparison-of-single-and-multitask-learning","title":"Comparison of single and multitask learning for predicting cognitive decline based on MRI data","arxiv_id":"2109.10266","date":"2021-09-21","proceeding":null,"authors":["Vandad Imani","Mithilesh Prakash","Marzieh Zare","Jussi Tohka"],"abstract":"The Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) is a neuropsychological tool that has been designed to assess the severity of cognitive symptoms of dementia. Personalized prediction of the changes in ADAS-Cog scores could help in timing therapeutic interventions in dementia and at-risk populations. In the present work, we compared single and multitask learning approaches to predict the changes in ADAS-Cog scores based on T1-weighted anatomical magnetic resonance imaging (MRI). In contrast to most machine learning-based prediction methods ADAS-Cog changes, we stratified the subjects based on their baseline diagnoses and evaluated the prediction performances in each group. Our experiments indicated a positive relationship between the predicted and observed ADAS-Cog score changes in each diagnostic group, suggesting that T1-weighted MRI has a predictive value for evaluating cognitive decline in the entire AD continuum. We further studied whether correction of the differences in the magnetic field strength of MRI would improve the ADAS-Cog score prediction. The partial least square-based domain adaptation slightly improved the prediction performance, but the improvement was marginal. In summary, this study demonstrated that ADAS-Cog change could be, to some extent, predicted based on anatomical MRI. Based on this study, the recommended method for learning the predictive models is a single-task regularized linear regression due to its simplicity and good performance. It appears important to combine the training data across all subject groups for the most effective predictive models.","url_abs":"https://arxiv.org/abs/2109.10266v1","url_pdf":"https://arxiv.org/pdf/2109.10266v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"comparison-of-single-and-multitask-learning","repo_url":"https://github.com/vandadim/adas_mri","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[{"task_slug":"diagnostic","task_name":"Diagnostic"},{"task_slug":"domain-adaptation","task_name":"Domain Adaptation"},{"task_slug":"multi-task-learning","task_name":"Multi-Task Learning"},{"task_slug":"multi-target-regression","task_name":"Multi-target regression"},{"task_slug":"predicate-detection","task_name":"Predicate Detection"},{"task_slug":"prediction","task_name":"Prediction"}],"methods":[{"method_slug":"linear-regression","method_name":"Linear Regression"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}