{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/co-data-learning-for-bayesian-additive","title":"Co-data Learning for Bayesian Additive Regression Trees","arxiv_id":"2311.09997","date":"2023-11-16","proceeding":null,"authors":["Jeroen M. Goedhart","Thomas Klausch","Jurriaan Janssen","Mark A. van de Wiel"],"abstract":"Medical prediction applications often need to deal with small sample sizes compared to the number of covariates. Such data pose problems for prediction and variable selection, especially when the covariate-response relationship is complicated. To address these challenges, we propose to incorporate co-data, i.e. external information on the covariates, into Bayesian additive regression trees (BART), a sum-of-trees prediction model that utilizes priors on the tree parameters to prevent overfitting. To incorporate co-data, an empirical Bayes (EB) framework is developed that estimates, assisted by a co-data model, prior covariate weights in the BART model. The proposed method can handle multiple types of co-data simultaneously. Furthermore, the proposed EB framework enables the estimation of the other hyperparameters of BART as well, rendering an appealing alternative to cross-validation. We show that the method finds relevant covariates and that it improves prediction compared to default BART in simulations. If the covariate-response relationship is nonlinear, the method benefits from the flexibility of BART to outperform regression-based co-data learners. Finally, the use of co-data enhances prediction in an application to diffuse large B-cell lymphoma prognosis based on clinical covariates, gene mutations, DNA translocations, and DNA copy number data. Keywords: Bayesian additive regression trees; Empirical Bayes; Co-data; High-dimensional data; Omics; Prediction","url_abs":"https://arxiv.org/abs/2311.09997v2","url_pdf":"https://arxiv.org/pdf/2311.09997v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"co-data-learning-for-bayesian-additive","repo_url":"https://github.com/JeroenGoedhart/EB_coBART_paper","is_official":1,"mentioned_in_paper":0,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[{"task_slug":"prediction","task_name":"Prediction"},{"task_slug":"prognosis","task_name":"Prognosis"},{"task_slug":"variable-selection","task_name":"Variable Selection"},{"task_slug":"regression-1","task_name":"regression"}],"methods":[{"method_slug":"adam","method_name":"Adam"},{"method_slug":"attention","method_name":"Attention"},{"method_slug":"bart","method_name":"BART"},{"method_slug":"bpe","method_name":"BPE"},{"method_slug":"dense-connections","method_name":"Dense Connections"},{"method_slug":"dropout","method_name":"Dropout"},{"method_slug":"layer-normalization","method_name":"Layer Normalization"},{"method_slug":"linear-layer","method_name":"Linear Layer"},{"method_slug":"multi-head-attention","method_name":"Multi-Head Attention"},{"method_slug":"residual-connection","method_name":"Residual Connection"},{"method_slug":"softmax","method_name":"Softmax"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}