{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/chronic-stress-may-disrupt-covariant","title":"Chronic stress may disrupt covariant fluctuations of vitamin D and cortisol plasma levels in pregnant sheep during the last trimester: a preliminary report","arxiv_id":"1904.06377","date":"2019-08-12","proceeding":null,"authors":[],"abstract":"Psychosocial stress during pregnancy is a known contributor to preterm birth,\nbut also has been increasingly appreciated as an in utero insult acting\nlong-term on prenatal and postnatal neurodevelopmental trajectories. These\nevents impact many information molecules, including both vitamin D and\ncortisol. Both have been linked to low birth premature babies. Cortisol tends\nto be further elevated in women, while vitamin D tends to be decreased from\ntheir normal levels during pregnancy. One facilitates labor in part by\nelevating placental CRH, the other by limiting CRH in placental tissue. Both\nare linked to managing adversity. Studies in large animal models with high\nresemblance to human physiology are sparse to model the changes induced by such\nstress exposure. Using an established pregnant sheep model of stress during\nhuman development, here we focused on measuring the changes in maternal Vitamin\nD and cortisol responses due to chronic inescapable stress mimicking daily\nchallenges in the last trimester of human pregnancy. The present pilot data\nshow that chronic maternal stress during pregnancy results in endocrine and\nmetabolic chronic habituation paralleled by sensitization to acute stress\nchallenges. Chronic stress appears to disrupt a physiological relationship\nbetween oscillations of vitamin D and cortisol. These speculations need to be\nexplored in future studies.","url_abs":"http://arxiv.org/abs/1904.06377v3","url_pdf":"http://arxiv.org/pdf/1904.06377v3.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"chronic-stress-may-disrupt-covariant","repo_url":"https://github.com/martinfrasch/stressed_sheep","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":1,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}