{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/anti-seizure-medication-tapering-is","title":"Anti-seizure medication tapering correlates with daytime delta band power reduction in the cortex","arxiv_id":"2405.01385","date":"2024-05-02","proceeding":null,"authors":["Guillermo M. Besne","Nathan Evans","Mariella Panagiotopoulou","Billy Smith","Fahmida A Chowdhury","Beate Diehl","John S Duncan","Andrew W McEvoy","Anna Miserocchi","Jane de Tisi","Mathew Walker","Peter N. Taylor","Chris Thornton","Yujiang Wang"],"abstract":"Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, despite their potential impact on research and clinical practice. We examined over 3000 hours of intracranial EEG recordings in 32 subjects during long-term monitoring, of which 22 underwent concurrent ASM tapering. We estimated ASM plasma levels based on known pharmaco-kinetics of all the major ASM types. We found an overall decrease in the power of delta band activity around the period of maximum medication withdrawal in most (80%) subjects, independent of their epilepsy type or medication combination. The degree of withdrawal correlated positively with the magnitude of delta power decrease. This dose-dependent effect was evident across all recorded cortical regions during daytime; but not in sub-cortical regions, or during night time. We found no evidence of a differential effect in seizure onset, spiking, or pathological brain regions. The finding of decreased delta band power during ASM tapering agrees with previous literature. Our observed dose-dependent effect indicates that monitoring ASM levels in cortical regions may be feasible for applications such as medication reminder systems, or closed-loop ASM delivery systems. ASMs are also used in other neurological and psychiatric conditions, making our findings relevant to a general neuroscience and neurology audience.","url_abs":"https://arxiv.org/abs/2405.01385v4","url_pdf":"https://arxiv.org/pdf/2405.01385v4.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"anti-seizure-medication-tapering-is","repo_url":"https://github.com/cnnp-lab/2024_asm_eeg","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[{"task_slug":"eeg-1","task_name":"EEG"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}