{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/analysis-of-the-first-genetic-engineering","title":"Analysis of the first Genetic Engineering Attribution Challenge","arxiv_id":"2110.11242","date":"2021-10-14","proceeding":null,"authors":["Oliver M. Crook","Kelsey Lane Warmbrod","Greg Lipstein","Christine Chung","Christopher W. Bakerlee","T. Greg McKelvey Jr.","Shelly R. Holland","Jacob L. Swett","Kevin M. Esvelt","Ethan C. Alley","William J. Bradshaw"],"abstract":"The ability to identify the designer of engineered biological sequences -- termed genetic engineering attribution (GEA) -- would help ensure due credit for biotechnological innovation, while holding designers accountable to the communities they affect. Here, we present the results of the first Genetic Engineering Attribution Challenge, a public data-science competition to advance GEA. Top-scoring teams dramatically outperformed previous models at identifying the true lab-of-origin of engineered sequences, including an increase in top-1 and top-10 accuracy of 10 percentage points. A simple ensemble of prizewinning models further increased performance. New metrics, designed to assess a model's ability to confidently exclude candidate labs, also showed major improvements, especially for the ensemble. Most winning teams adopted CNN-based machine-learning approaches; however, one team achieved very high accuracy with an extremely fast neural-network-free approach. Future work, including future competitions, should further explore a wide diversity of approaches for bringing GEA technology into practical use.","url_abs":"https://arxiv.org/abs/2110.11242v1","url_pdf":"https://arxiv.org/pdf/2110.11242v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"analysis-of-the-first-genetic-engineering","repo_url":"https://github.com/willbradshaw/geac","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":1,"framework":"none","reach":null}],"tasks":[{"task_slug":"diversity","task_name":"Diversity"}],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"syntology_url":null,"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}