{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/alphafold2-can-predict-structural-and","title":"AlphaFold2 can predict single-mutation effects","arxiv_id":"2204.06860","date":"2022-04-14","proceeding":null,"authors":["John M. McBride","Konstantin Polev","Amirbek Abdirasulov","Vladimir Reinharz","Bartosz A. Grzybowski","Tsvi Tlusty"],"abstract":"AlphaFold2 (AF) is a promising tool, but is it accurate enough to predict single mutation effects? Here, we report that the localized structural deformation between protein pairs differing by only 1-3 mutations -- as measured by the effective strain -- is correlated across \\num{3901} experimental and AF-predicted structures. Furthermore, analysis of ${\\sim} 11000$ proteins shows that the local structural change correlates with various phenotypic changes. These findings suggest that AF can predict the range and magnitude of single-mutation effects on average, and we propose a method to improve precision of AF predictions and to indicate when predictions are unreliable.","url_abs":"https://arxiv.org/abs/2204.06860v7","url_pdf":"https://arxiv.org/pdf/2204.06860v7.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"alphafold2-can-predict-structural-and","repo_url":"https://github.com/mirabdi/af2-analysis-code","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null},{"paper_slug":"alphafold2-can-predict-structural-and","repo_url":"https://github.com/mirabdi/pdanalysis","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}