{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/a-stability-driven-protocol-for-drug-response","title":"A stability-driven protocol for drug response interpretable prediction (staDRIP)","arxiv_id":"2011.06593","date":"2020-11-12","proceeding":null,"authors":["Xiao Li","Tiffany M. Tang","Xuewei Wang","Jean-Pierre A. Kocher","Bin Yu"],"abstract":"Modern cancer -omics and pharmacological data hold great promise in precision cancer medicine for developing individualized patient treatments. However, high heterogeneity and noise in such data pose challenges for predicting the response of cancer cell lines to therapeutic drugs accurately. As a result, arbitrary human judgment calls are rampant throughout the predictive modeling pipeline. In this work, we develop a transparent stability-driven pipeline for drug response interpretable predictions, or staDRIP, which builds upon the PCS framework for veridical data science (Yu and Kumbier, 2020) and mitigates the impact of human judgment calls. Here we use the PCS framework for the first time in cancer research to extract proteins and genes that are important in predicting the drug responses and stable across appropriate data and model perturbations. Out of the 24 most stable proteins we identified using data from the Cancer Cell Line Encyclopedia (CCLE), 18 have been associated with the drug response or identified as a known or possible drug target in previous literature, demonstrating the utility of our stability-driven pipeline for knowledge discovery in cancer drug response prediction modeling.","url_abs":"http://arxiv.org/abs/2011.06593v2","url_pdf":"http://arxiv.org/pdf/2011.06593v2.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"links_only","authors_date_abstract":"arXiv metadata, CC0 1.0 (https://info.arxiv.org/help/license), from the Kaggle arXiv metadata snapshot of 2026-09-12"},"code_links":[{"paper_slug":"a-stability-driven-protocol-for-drug-response","repo_url":"https://github.com/Yu-Group/staDRIP","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"none","reach":null}],"tasks":[],"methods":[],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":"https://app.syntology.ai/?focus=2011.06593","mcp":{"get_harvested_code_for_paper":{"arxiv_id":"2011.06593"}},"developers":"https://syntology.ai/developers","read_at":"2026-09-24T18:15:14+00:00","read_at_is":"when the build read Syntology's graph, not when any sample ran","claim":"Per-sample execution status on synthesized fixtures; not a correctness claim about the paper. Samples come from repositories linked to the paper, official or community; repo_kind says which.","repos":[{"provenance":"external:paperswithcode_snapshot_2025-07-28","url":"https://github.com/Yu-Group/staDRIP","reach":null}],"summary":{"ran":1},"by_repo_kind":{"official":{"samples":1,"ran":1,"repositories":1}},"repo_kind_vocabulary":{"official":"The archive marks this repository official for the paper","named_in_paper":"The archive records that the paper mentions this repository; it is not marked official","listed":"In the archive's code links for this paper, not marked official and not recorded as mentioned in the paper","found_in_text":"Syntology found this repository in the paper's own text; whether it is the authors' implementation is not asserted","community":"Not in the archive's code links for this paper; a community repository Syntology harvested"},"n_pointer_only_for_licence":0,"samples":[{"code_sha256_prefix":"4c83c0652b39b2a8","entry":"XVAE","repo":"Yu-Group/staDRIP","repo_kind":"official","path":"xvae/mayo_vae.py","file_url":"https://github.com/Yu-Group/staDRIP/blob/HEAD/xvae/mayo_vae.py","link_basis":"first_harvest_node","language":"python","status":"ran","verification_level":1,"contract_check":null,"metamorphic_tier":"deterministic","behaviour_fingerprint":false,"licence":"MIT","inline_ok":true,"mcp_get_code":{"code_sha256":"4c83c0652b39b2a8"}}]},"arxiv_metadata":null,"syntology_extracted_results":null}