{"about":{"site":"https://codewithpapers.app","non_affiliation":"Code with Papers and Syntology are not affiliated with, endorsed by, or sponsored by Papers with Code, Meta, or the pwc-archive mirror.","licence":"CC BY-SA 4.0","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","attribution":"https://codewithpapers.app/attribution","modified":"archive material modified by Syntology; see the attribution page"},"url":"/paper/a-heterogeneous-network-based-contrastive","title":"A Heterogeneous Network-based Contrastive Learning Approach for Predicting Drug-Target Interaction","arxiv_id":"2411.00801","date":"2024-10-20","proceeding":null,"authors":["Junwei Hu","Michael Bewong","Selasi Kwashie","Wen Zhang","Vincent M. Nofong","Guangsheng Wu","Zaiwen Feng"],"abstract":"Drug-target interaction (DTI) prediction is crucial for drug development and repositioning. Methods using heterogeneous graph neural networks (HGNNs) for DTI prediction have become a promising approach, with attention-based models often achieving excellent performance. However, these methods typically overlook edge features when dealing with heterogeneous biomedical networks. We propose a heterogeneous network-based contrastive learning method called HNCL-DTI, which designs a heterogeneous graph attention network to predict potential/novel DTIs. Specifically, our HNCL-DTI utilizes contrastive learning to collaboratively learn node representations from the perspective of both node-based and edge-based attention within the heterogeneous structure of biomedical networks. Experimental results show that HNCL-DTI outperforms existing advanced baseline methods on benchmark datasets, demonstrating strong predictive ability and practical effectiveness. The data and source code are available at https://github.com/Zaiwen/HNCL-DTI.","url_abs":"https://arxiv.org/abs/2411.00801v1","url_pdf":"https://arxiv.org/pdf/2411.00801v1.pdf","source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28","licence_url":"https://creativecommons.org/licenses/by-sa/4.0/legalcode","row_kind":"abstracts"},"code_links":[{"paper_slug":"a-heterogeneous-network-based-contrastive","repo_url":"https://github.com/zaiwen/hncl-dti","is_official":1,"mentioned_in_paper":1,"mentioned_in_github":0,"framework":"pytorch","reach":null}],"tasks":[{"task_slug":"contrastive-learning","task_name":"Contrastive Learning"},{"task_slug":"graph-attention","task_name":"Graph Attention"}],"methods":[{"method_slug":"attention","method_name":"Attention"},{"method_slug":"contrastive-learning","method_name":"Contrastive Learning"},{"method_slug":"softmax","method_name":"Softmax"}],"datasets_introduced":[],"methods_introduced":[],"results":[],"syntology":{"atlas_url":null,"mcp":null,"developers":"https://syntology.ai/developers"},"arxiv_metadata":null,"syntology_extracted_results":null}