{"url":"/dataset/l1000","name":"L1000","full_name":null,"description_markdown":"The **L1000** dataset consists of ~1,400,000 gene-expression profiles on the responses of ~50 human cell lines to one of ~20,000 compounds across a range of concentrations. The L1000 dataset and its normalization versions10 were recently widely used in drug repurposing and discovery.\r\n\r\nDescription from: [A deep learning framework for high-throughput mechanism-driven phenotype compound screening and its application to COVID-19 drug repurposing](https://www.nature.com/articles/s42256-020-00285-9)\r\n\r\nPublication introducing the dataset: [A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles](https://pubmed.ncbi.nlm.nih.gov/29195078/)","description_withheld":null,"homepage":"https://clue.io/","introduced_date":null,"introduced_date_note":null,"introduced_by":null,"license":null,"modalities":[],"tasks":[],"languages":[],"variants":["L1000"],"data_loaders":[],"num_papers_in_archive":0,"source":{"archive":"pwc-archive (Hugging Face), CC BY-SA 4.0","snapshot":"2025-07-28"},"benchmarks":[],"papers_with_a_benchmark_row":[],"syntology_totals":{"read_at":"2026-09-24T18:15:14+00:00","papers_with_samples":0,"samples_harvested":0,"samples_ran":0,"samples_unverified":0,"pointer_only_for_licence":0,"papers_with_no_sample_that_ran":0,"note":"the per-paper counts above, summed; not a rate"},"papers_note":"The archive never published its papers-using-dataset list; these are papers with a leaderboard row on this dataset's benchmarks."}